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Smart EPA

  • 3500

Smart EPA

Essential Fatty Acids from Coldwater Fish

This ultra pure, molecularly distilled oil from anchovies and sardines contains one of the highest concentrations of eicosapentaenoic acid (EPA) available, with one softgel meeting the ISSFAL recommendation of 650 mg omega-3 per day. EPA is a conditionally essential fatty acid. OmegaPure EPA™, like all of XYMOGEN®’s OmegaPure oils, is third party tested for purity and freshness.*


*The statements below have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Take one to two softgels with water daily, or as directed by your healthcare practitioner.

Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.

Does Not Contain

Wheat, gluten, corn, yeast, soy protein, dairy products, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.


Keep closed in a cool, dry place out of reach of children.

Other Ingredients

Softgel (bovine gelatin, vegetable glycerin, purified water), and mixed tocopherols.


  • Support for manufacture of prostaglandins*
  • Support for healthy cell membranes*
  • Support for cardiovascular system*
  • Support for healthy cognition/mood/behavior*


*The statements below have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Eicosapentaenoic acid (EPA) is a long chain omega-3 fatty acid. Although EPA does not significantly affect clotting factors, it does reduce blood viscosity [1] and blood triglycerides.[2] The finding of a low incidence of acute myocardial infarction among native Greenland Eskimos launched interest in EPA in the 1970’s.[3] EPA is a precursor for the platelet aggregation inhibitor, prostaglandin-3, and for the eicasonoids, thromboxane-3 and leukotriene-5. It competes with arachadonic acid for inclusion in the lipoxygenase and cyclooxygenase pathways.*[4]

There is some evidence that EPA supplementation benefits mental health, perhaps due to its healthful effect upon membrane fluidity. Studies showing improvement in mood and behavior have not only demonstrated the effectiveness of 1-2 grams of EPA alone or with standard treatment, but have demonstrated superiority in the effectiveness of the ethyl form, which is identical to the form contained in Smart EPA.*[5]

An eight-week placebo-controlled study with 500mg three times daily of ethyl-EPA showed a modest reduction in the number of daily menopausal hot flashes.[6] A similarly designed study showed improvement in menopausalrelated poor mood.[7]Whether or not supplementation with EPA inhibits lipolysis is not clear; yet, it has been shown to reduce weight loss in cachetic patients. However, this is possibly due to attenuation of the degradation of skeletal muscle.*[8]

Besides its presence in breast milk, algae, and the vegetable, purslane, this polyunsaturated fatty acid (PUFA) is mostly available through consumption of fatty fish (such as sardines and anchovies) and/or their oils, the sources for Smart EPA. This fatty acid may also be obtained by the conversion of alpha linolenic acid (ALA), although conversion is generally inefficient.*

Hughes Center For Functional Medicine’s Smart EPA is processed under strictly controlled conditions according to the acceptable published standards of the Council for Responsible Nutrition (CRN) and the World Health Organization (WHO), as well as the most stringent current standard, the International Fish Oils Standard (IFOS). The oil is molecularly distilled under vacuum. Independent third party testing confirms freshness, purity, and safety.*

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